1-Ethylpiperidin-4-amine → N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide

HRID 2234461Notes

Reaction equation

HRID 2234461 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:6](N[C@@H]1CCN(C)C1)=[O:7].[CH2:21]([N:23]1[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24]1)[CH3:22]>>[CH2:21]([N:23]1[CH2:28][CH2:27][CH:26]([NH:29][C:6](=[O:7])[C:5]2[CH:15]=[CH:16][C:17]([N+:18]([O-:20])=[O:19])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:25][CH2:24]1)[CH3:22]

Participants

3

Reactant 2

HCID 37349901-Ethylpiperidin-4-amineHCID 686830363-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]-4-nitro-benzamide

Product 1

HCID 68681536N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 188, on a 9.28 mmol scale utilising 1-ethylpiperidin-4-amine (Fluorochem; 1.19 g, 9.28 mmol), as a brown solid (3.3 g, 100%)

Sources & evidence

ORD record
ord-efde4b69e3844a7a8d46a2507a312c48
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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