N,N-Dimethylethylenediamine → N-(2-(dimethylamino)ethyl)-3-methoxy-4-nitrobenzamide

HRID 2234465Notes

Reaction equation

HRID 2234465 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:6]([NH:8][C@@H:9]1C[CH2:12][N:11]([CH3:14])[CH2:10]1)=[O:7].CN(C)CCN>>[CH3:14][N:11]([CH3:12])[CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]1[CH:15]=[CH:16][C:17]([N+:18]([O-:20])=[O:19])=[C:3]([O:2][CH3:1])[CH:4]=1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 686830363-methoxy-N-[(3R)-1-methylpyrrolidin-3-yl]-4-nitro-benzamide

Product 1

HCID 68683674N-(2-(dimethylamino)ethyl)-3-methoxy-4-nitrobenzamide

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 188, on a 9.28 mmol scale utilising N,N-dimethylethane-1,2-diamine (Aldrich; 818 mg, 9.28 mmol), as a brown solid (2.5 g, 100%)

Sources & evidence

ORD record
ord-935d4974ef164d08b8b018d69c38fffd
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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