Methyl iodide → 10-Chloro-4,4-diethyl-6-methyl-2-propan-2-yl-2,6,9,11-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-5-one

HRID 2234468Notes

Reaction equation

[Cl:1][C:2]1[N:12]=[C:11]2[C:5]([NH:6][C:7](=[O:20])[C:8]([CH2:18][CH3:19])([CH2:16][CH3:17])[CH2:9][N:10]2[CH:13]([CH3:15])[CH3:14])=[CH:4][N:3]=1.[CH3:21]I.[H-].[Na+]>CC(N(C)C)=O.C(Cl)Cl.C(OCC)C>[Cl:1][C:2]1[N:12]=[C:11]2[C:5]([N:6]([CH3:21])[C:7](=[O:20])[C:8]([CH2:16][CH3:17])([CH2:18][CH3:19])[CH2:9][N:10]2[CH:13]([CH3:15])[CH3:14])=[CH:4][N:3]=1

Participants

Conditions

Temperature: 3 °C

Procedure

To a stirred solution of 10-chloro-4,4-diethyl-2-propan-2-yl-2,6,9,11-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-5-one (Intermediate 197; 2.7 g, 9.1 mmol) in DMA (50 mL) under nitrogen was added methyl iodide (0.627 mL, 10.0 mmol). The mixture was cooled on an ice/water bath to 3° C., and sodium hydride (60% mineral oil dispersion; 0.567 g, 11.8 mmol) added in one portion. The reaction was stirred overnight. The reaction was evaporated to dryness to afford a yellow solid, this was quenched with saturated NH4Cl(aq) (50 mL), extracted with DCM (3×100 mL), dried (MgSO4) and evaporated to yield a yellow solid. This was dissolved in a minimum amount of DCM, diethyl ether was added and the system was sonicated to afford an off white solid. (2.24 g, 80%)

Workup

customThe reaction was evaporated to dryness
customto afford a yellow solid
customthis was quenched with saturated NH4Cl(aq) (50 mL)
extractionextracted with DCM (3×100 mL)
dry with materialdried (MgSO4)
customevaporated
customto yield a yellow solid
additionwas added
customthe system was sonicated
customto afford an off white solid

Sources & evidence

ORD record: ord-c3c7ed1897e14bcf99adb698204a6243
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709471B2

Reaction notes

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