反应详情

Methyl2-(aminomethyl)-2-ethyl-butanoate (Intermediate 201; 8 g, 50 mmol) and acetone (4.35 g, 75 mmol) were added to methanol (230 mL) and stirred for 10 minutes before the rapid addition of sodium triacetoxyborohydride (15.9 g, 75 mmol). The reaction was stirred overnight before being evaporated to dryness. The residue was quenched with saturated K2CO3(aq) (100 mL), extracted with DCM (3×150 mL), dried and solvent evaporated to yield a dark liquids. Purification was achieved via distillation (65 oC @ 0.18 mbar) to yield the title compound as clear oil (5.3 g, 53%)

1. custombefore being evaporated to dryness
2. customThe residue was quenched with saturated K2CO3(aq) (100 mL)
3. extractionextracted with DCM (3×150 mL)
4. customdried
5. customsolvent evaporated
6. customto yield a dark liquids
7. customPurification
8. distillationwas achieved via distillation (65 oC @ 0.18 mbar)