反应详情

To a solution of 2′-chloro-9′-isopropyl-8′,9′-dihydrospiro[cyclopropane-1,7′-pyrimido[5,4-b][1,4]diazepin]-6′(5′H)-one (Intermediate 209; 5.055 g, 19 mmol) in DMA (300 mL) was added methyl iodide (1.305 mL, 20.9 mmol), followed by sodium hydride (60% mineral oil dispersion; 814 mg, 20.33 mmol). The mixture was stirred at room temperature for 30 minutes. The DMA was removed in vacuo, then water (50 mL) was added. The product precipitated as a sticky gum, which turned into a solid on sonication. The solid was collected by filtration to give a brown powder. This material was dissolved in DCM and dried over sodium sulfate, then purified by column chromatography, eluting with 25% ethyl acetate in hexane, to yield the title compound as a white solid (3.73 g, 70%)

1. customThe DMA was removed in vacuo
2. additionwater (50 mL) was added
3. customThe product precipitated as a sticky gum, which
4. customturned into a solid on sonication
5. filtrationThe solid was collected by filtration
6. customto give a brown powder
7. dry with materialdried over sodium sulfate
8. custompurified by column chromatography
9. washeluting with 25% ethyl acetate in hexane