2,2-Dimethyaminoethylamine → 4-amino-3-chloro-N-(2-dimethylaminoethyl)benzamide

HRID 2234480Notes

Reaction equation

HRID 2234480 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH:9]2[CH2:14]CN(CC)CC2)=[O:7])=[CH:4][C:3]=1[Cl:19].[CH3:20][NH:21][CH:22](NC)CN>>[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH2:14][N:21]([CH3:22])[CH3:20])=[O:7])=[CH:4][C:3]=1[Cl:19]

Participants

3

Reactant 2

HCID 571635242,2-DimethyaminoethylamineHCID 643214944-amino-3-chloro-N-(1-ethyl-4-piperidyl)benzamide

Product 1

HCID 597636804-amino-3-chloro-N-(2-dimethylaminoethyl)benzamide

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 212, on a 15 mmol scale utilising 2,2-Dimethyaminoethylamine (Aldrich; 1.455 g, 16.5 mmol), as a white solid (1.45 g, 40%).

Sources & evidence

ORD record
ord-97198d5f9595424fa0a4eb94b422e518
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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