N,N-Dimethyl-1,3-propanediamine → 4-amino-3-chloro-N-(3-dimethylaminopropyl)benzamide

HRID 2234481Notes

Reaction equation

HRID 2234481 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH:9]2C[CH2:13][N:12]([CH2:15]C)[CH2:11][CH2:10]2)=[O:7])=[CH:4][C:3]=1[Cl:19].CN(C)CCCN>>[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][N:12]([CH3:15])[CH3:13])=[O:7])=[CH:4][C:3]=1[Cl:19]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 643214944-amino-3-chloro-N-(1-ethyl-4-piperidyl)benzamide

Product 1

HCID 643181374-amino-3-chloro-N-(3-dimethylaminopropyl)benzamide

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 212, on a 15 mmol scale utilising 3-Dimethylamino-1-propylamine (Aldrich; 1.685 g, 16.5 mmol), as a tan coloured solid (3.25 g, 85%).

Sources & evidence

ORD record
ord-0322277ba13746f9a1ec58a9ac7b2898
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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