HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(Azetidin-1-yl)cyclohexan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl N-[4-(azetidin-1-yl)cyclohexyl]carbamate | HCID 68684591 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Azetidin-1-yl)cyclohexan-1-amine | HCID 68682523 | — |
Reaction Steps
tert-butyl N-[4-(azetidin-1-yl)cyclohexyl]carbamate (Intermediate 227; 260 mg, 1.01 mmol) was taken up in DCM (3 mL) and TFA (2 mL) and stirred at ambient temperature for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709471B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-99dc87ea3a1f4d8f814153cf1a8edbc3 |
| Source note | uspto-grants-2010_05 |