Trifluoroacetic acid → 4-(Azetidin-1-yl)cyclohexan-1-amine

HRID 2234493Notes

Reaction equation

HRID 2234493 reaction equation
[N:1]1([CH:5]2[CH2:10][CH2:9][CH:8]([NH:11]C(=O)OC(C)(C)C)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:1]1([CH:5]2[CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH2:6]2)[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68684591tert-butyl N-[4-(azetidin-1-yl)cyclohexyl]carbamate2×

Product 1

HCID 686825234-(Azetidin-1-yl)cyclohexan-1-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl N-[4-(azetidin-1-yl)cyclohexyl]carbamate (Intermediate 227; 260 mg, 1.01 mmol) was taken up in DCM (3 mL) and TFA (2 mL) and stirred at ambient temperature for 3 hours.

Sources & evidence

ORD record
ord-99dc87ea3a1f4d8f814153cf1a8edbc3
Source dataset
uspto-grants-2010_05
Patent number
US07709471B2

Reaction notes

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