Cyclopentanone → Methyl2-[(cyclopentylamino)methyl]-2-ethyl-butanoate

HRID 2234507Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:14])[C:4]([CH2:12][CH3:13])([CH2:7][NH:8][CH:9]([CH3:11])[CH3:10])[CH2:5][CH3:6].[C:15]1(=O)CCC[CH2:16]1>>[CH3:1][O:2][C:3](=[O:14])[C:4]([CH2:7][NH:8][CH:9]1[CH2:10][CH2:16][CH2:15][CH2:11]1)([CH2:12][CH3:13])[CH2:5][CH3:6]

Participants

Reactant 2

HCID 8452Cyclopentanone

HCID 86617586Methyl2-ethyl-2-[(propan-2-ylamino)methyl]butanoate

Product 1

HCID 68684960Methyl2-[(cyclopentylamino)methyl]-2-ethyl-butanoate

Procedure

The title compound was prepared by an analogous method to the preparation of Intermediate 200, on a 50 mmol scale utilising Cyclopentanone (Aldrich; 6.33 g, 75 mmol), and distillation at 50° C. and 0.53 mbar pressure, as a clear oil (7.5 g, 65%)

Sources & evidence

ORD record: ord-8e6f5bfec7c5450e8aa0a3bf0972a4fd
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07709471B2

Reaction notes

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