HCID 15225176, compound → (2R)-Acetamido(cyclohexyl)acetic acid

HRID 2234821Notes

Reaction equation

HRID 2234821 reaction equation
[C:1]([NH:4][C@H:5]([C:9]1[CH2:14][CH:13]=[CH:12][CH2:11][CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]>CO.[Pt]=O>[C:1]([NH:4][C@H:5]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 15225176HCID 15225176, compound

Product 1

HCID 10921523(2R)-Acetamido(cyclohexyl)acetic acidYield 75%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

To a solution of 15 g of (R)-(acetylamino) (1,4-cyclohexadiene-1-yl)acetic acid in 500 mL of methanol was added 500 mg of platinum oxide, and the mixture was stirred for 4 hours under hydrogen gas atmosphere. Then, the reaction mixture was filtrated and the filtrate was condensed. The residue was recrystallized from ethanol to give 11.4 g (75%) of the title compound.

Workup

  1. filtrationThen, the reaction mixture was filtrated
  2. customcondensed
  3. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-05d03532a94b489f8d4e2f61c55f6449
Source dataset
uspto-grants-2010_05
Patent number
US07713972B2

Reaction notes

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