HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-(6-Bromo-4-methyl-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | 6-bromo-4-methyl-1,2,4-triazine-3,5(2h,4h)-dione | HCID 260564 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(6-Bromo-4-methyl-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionitrile | HCID 59298828 | 93.2% |
Reaction Steps
2.4 g (11.6 mmol) of triazine 2a and 7 ml (106 mmol) of acrylonitrile are placed in 24 ml of a solution of pyridine and water (1:1) at reflux for 3 h. After concentration the reaction medium is extracted by AcOEt, and after drying on MgSO4 the organic phases are dry concentrated. 2.8 g of solid 3a are isolated and then washed with ether (yield=93%). TLC silica gel 60 F 254 Merck, petroleum ether:AcOEt 70:30, Rf=0.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713971B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-a938792dac9a4f6bb9b9d04e564ddbdf |
| Source note | uspto-grants-2010_05 |