反应详情

温度

120 °C

Compound 56 is prepared according to synthesis method 1: 1.1 g (4.4 mmol) of derivative 13b and 1 g (3.7 mmol) of triazine 4a are placed in 10 ml of nBuOH in the presence of 1.3 ml (9.3 mmol) of triethylamine. This mixture is stirred at 120° C. for 24 h. After dry concentration of the reaction medium, the residue obtained is taken up in H2O and extracted with AcOEt. The organic phases are dried on MgSO4, then dry concentrated. The oil obtained is purified by flash chromatography on silica (petroleum ether:AcOEt 90:10). 0.4 g of compound 56 is isolated in the form of an oil (yield=27%).

1. customCompound 56 is prepared
2. customaccording to synthesis method 1
3. customAfter dry concentration of the reaction medium
4. customthe residue obtained
5. extractionextracted with AcOEt
6. customThe organic phases are dried on MgSO4
7. customdry
8. concentrationconcentrated
9. customThe oil obtained
10. customis purified by flash chromatography on silica (petroleum ether:AcOEt 90:10)