Maleimide → HCID 68495264, compound

HRID 2234879Notes

Reaction equation

HRID 2234879 reaction equation
[NH:1]1[C:5](=O)[CH:4]=[CH:3][C:2]1=O.[F:8][C:9]([F:26])([F:25])[C:10]1[CH:19]=[C:18]([S:20][CH2:21][C:22]([NH2:24])=[O:23])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>>[C:3]1([C:21]2[C:22](=[O:23])[NH:24][C:22](=[O:23])[C:21]=2[S:20][C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([C:9]([F:8])([F:25])[F:26])[CH:19]=2)[C:4]2=[C:5]3[C:17](=[CH:12][CH:13]=[CH:14]2)[CH2:18][CH2:19][CH2:10][N:1]3[CH:2]=1

Participants

3

Reactant 2

HCID 10935MaleimideHCID 67017020HCID 67017020, compound

Product 1

HCID 68495264HCID 68495264, compound

Procedure

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4¶-trifluoromethyl-quinolin-4-yl-sulfanyl)-pyrrole-2,5-dione was prepared according to Example 1, steps 1-6, employing 2-[[2-(trifluoromethyl)-4-quinolinyl]thio]acetamide in place of indole-3-acetamide in step 6. 1H NMR (CDCl3) 400 MHz δ: 8.3(d, 1H, J=7.6 Hz), 8.11(d, 1H, J=8.4 Hz), 8.05(s, 1H), 7.68-7.82(m, 4H), 7.23(s, 1H), 6.83(m, 2H), 4.21(t, 2H, J=6 Hz), 2.92(t, 2H, J=6 Hz), 2.21(m, 2H).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-a3250ba7dea04afa8353d90699094692
Source dataset
uspto-grants-2010_05
Patent number
US07713969B2

Reaction notes

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