4-Bromo-3-fluorobenzenesulfonyl chloride → 4-Bromo-N-{4-[cis-3,5-dimethyl-1-piperazinyl]-2-pyridinyl}-3-fluorobenzenesulfonamide

HRID 2234987Notes

Reaction equation

HRID 2234987 reaction equation
BrC1C=CC(S(NC2C=CN=C(Cl)C=2)(=O)=O)=CC=1.[CH3:19][C@H:20]1[NH:25][C@@H:24]([CH3:26])[CH2:23][N:22]([C:27]2[CH:32]=[CH:31][N:30]=[C:29]([NH2:33])[CH:28]=2)[CH2:21]1.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[CH:37][C:36]=1[F:45]>>[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([NH:33][C:29]2[CH:28]=[C:27]([N:22]3[CH2:23][C@H:24]([CH3:26])[NH:25][C@H:20]([CH3:19])[CH2:21]3)[CH:32]=[CH:31][N:30]=2)(=[O:43])=[O:42])=[CH:37][C:36]=1[F:45]

Participants

4

Reactant 3

HCID 27782184-Bromo-3-fluorobenzenesulfonyl chlorideHCID 589881294-[cis-3,5-Dimethyl-1-piperazinyl]-2-pyridinamineHCID 589881394-Bromo-N-(2-chloro-4-pyridinyl)benzenesulfonamide

Product 1

HCID 589881534-Bromo-N-{4-[cis-3,5-dimethyl-1-piperazinyl]-2-pyridinyl}-3-fluorobenzenesulfonamide

Procedure

The title compound was prepared in a manner similar to 4-bromo-N-(2-chloro-4-pyridinyl)benzenesulfonamide (D3) using 4-[cis-3,5-dimethyl-1-piperazinyl]-2-pyridinamine (D21) and 4-bromo-3-fluorobenzenesulfonyl chloride as the starting materials. MS (ES+) m/e 443, 445 [M+H]+.

Sources & evidence

ORD record
ord-dcd55ef8d9d444acb3317c19a62510e4
Source dataset
uspto-grants-2010_05
Patent number
US07713978B2

Reaction notes

Loading…