N-[5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinyl]-2,2,2-trifluoroacetamide → N-{5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide

HRID 2234992Notes

Reaction equation

HRID 2234992 reaction equation
[CH3:1][C@H:2]1[N:7](CC2C=CC=CC=2)[C@@H:6]([CH3:15])[CH2:5][N:4]([C:16]2[CH:17]=[C:18]([NH:24][C:25](=[O:30])[C:26]([F:29])([F:28])[F:27])[C:19](OC)=[N:20][CH:21]=2)[CH2:3]1.C[C@H]1N[C@@H](C)CN(C2C=C(NC(=O)OC(C)(C)C)C=NC=2)C1>>[CH3:15][C@H:6]1[NH:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:16]2[CH:17]=[C:18]([NH:24][C:25](=[O:30])[C:26]([F:29])([F:27])[F:28])[CH:19]=[N:20][CH:21]=2)[CH2:5]1

Participants

3

Reactant 2

HCID 58988127N-[5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinyl]-2,2,2-trifluoroacetamideHCID 589881381,1-Dimethylethyl {5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinyl}carbamate

Product 1

HCID 58988131N-{5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide

Procedure

The title compound was prepared in a manner similar to N-[5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinyl]-2,2,2-trifluoroacetamide (D28) using 1,1-dimethylethyl {5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinyl}carbamate (D34) as the starting material. MS (ES+) m/e 303 [M+H]+.

Sources & evidence

ORD record
ord-bc76183db86b4a8684efb657874f148b
Source dataset
uspto-grants-2010_05
Patent number
US07713978B2

Reaction notes

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