1,4-Dioxane hydrochloride → HCID 68682431, compound

HRID 2234996Notes

Reaction equation

HRID 2234996 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][CH:10]=[C:11]([CH3:13])[CH:12]=2)[CH:5]=[CH:4][C:3]=1[S:14]([NH:17][C:18]1[N:23]=[C:22]([N:24]2[CH2:29][C@H:28]([CH3:30])[N:27](C(OC(C)(C)C)=O)[C@H:26]([CH3:38])[CH2:25]2)[CH:21]=[CH:20][C:19]=1[O:39][CH3:40])(=[O:16])=[O:15].Cl.O1CCOCC1>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][CH:10]=[C:11]([CH3:13])[CH:12]=2)[CH:5]=[CH:4][C:3]=1[S:14]([NH:17][C:18]1[C:19]([O:39][CH3:40])=[CH:20][CH:21]=[C:22]([N:24]2[CH2:29][C@H:28]([CH3:30])[NH:27][C@H:26]([CH3:38])[CH2:25]2)[N:23]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70882503HCID 70882503, compound

Product 1

HCID 68682431HCID 68682431, compoundYield 193.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl (2R,6S)-4-[6-({[2-chloro-4-(4-methyl-2-thienyl)phenyl]sulfonyl}amino)-5-(methyloxy)-2-pyridinyl]-2,6-dimethyl-1-piperazinecarboxylate (D14) (0.128 g) was dissolved in dioxane (5 mL) and 4N HCl/dioxane (5 mL) added and the reaction stirred at rt for 24 hours. The reaction mixture was evaporated to give the title compound as a pale yellow solid (E6) (0.111 g). MS (ES+) m/e 507/509 [M+H]+.

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-27946ca0012d46ca9f9881c229340210
Source dataset
uspto-grants-2010_05
Patent number
US07713978B2

Reaction notes

Loading…