HCID 70882504, compound → HCID 68682630, compound

HRID 2234997Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[CH:11][O:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[S:13]([NH:16][C:17]1[N:22]=[C:21]([N:23]2[CH2:28][C@H:27]([CH3:29])[N:26](C(OC(C)(C)C)=O)[C@H:25]([CH3:37])[CH2:24]2)[CH:20]=[CH:19][C:18]=1[O:38][CH3:39])(=[O:15])=[O:14]>Cl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[CH:11][O:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[S:13]([NH:16][C:17]1[C:18]([O:38][CH3:39])=[CH:19][CH:20]=[C:21]([N:23]2[CH2:28][C@H:27]([CH3:29])[NH:26][C@H:25]([CH3:37])[CH2:24]2)[N:22]=1)(=[O:14])=[O:15]

Participants

Conditions

Temperature: 35 °C

Procedure

1,1-Dimethylethyl (2R,6S)-4-[6-({[2-chloro-4-(3-furanyl)phenyl]sulfonyl}amino)-5-(methyloxy)-2-pyridinyl]-2,6-dimethyl-1-piperazinecarboxylate (D15) (0.170 g) was dissolved in 4N HCl/dioxane (6 mL) and the reaction stirred at 35° C. for 2 hours. The reaction mixture was evaporated and triturated with ethyl acetate/ether (×3) to give a white solid which was dried at 50° C. under high vac to give the compound as a white solid (E7)(0.119 g). MS (ES+) m/e 477/479 [M+H]+.

Workup

customThe reaction mixture was evaporated
customtriturated with ethyl acetate/ether (×3)
customto give a white solid which
customwas dried at 50° C. under high vac

Sources & evidence

ORD record: ord-cb9133b82f2a4b0ea172c720e855226f
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07713978B2

Reaction notes

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