Triethylamine hydrochloride → HCID 178478214, compound

HRID 2235008Notes

Reaction equation

HRID 2235008 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:5][CH:6]1[CH2:12][CH:11]2[N:13]([CH2:14][C:15]#[N:16])[CH:8]([CH2:9][CH2:10]2)[CH2:7]1.Cl.C(N(CC)CC)C.[N-:29]=[N+:30]=[N-:31].[Na+]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[O:5][CH:6]1[CH2:12][CH:11]2[N:13]([CH2:14][C:15]3[NH:31][N:30]=[N:29][N:16]=3)[CH:8]([CH2:9][CH2:10]2)[CH2:7]1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 11415683HCID 11415683, compound

Product 1

HCID 178478214HCID 178478214, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
61 °C

Procedure

To 1 g of [3-(3,4-dichloro-phenoxy)-8-aza-bicyclo[3.2.1]oct-8-yl]-acetonitrile in 25 ml anhydrous toluene was added 0.7 g of triethylamin hydrochloride and 0.3 g sodium azide. The reaction mixture was stirred at 60-62° C. for 5 days, the product precipitated from the mixture and was isolated by filtration. Yield 0.27 g (24%) Mp. 233-235° C. (sublimation).

Workup

  1. customthe product precipitated from the mixture
  2. customwas isolated by filtration

Sources & evidence

ORD record
ord-1f70a17816c04a1b90f7891c41bcfd4a
Source dataset
uspto-grants-2010_05
Patent number
US07713990B2

Reaction notes

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