Ethanol → HCID 68439912, compound

HRID 2235041Notes

Reaction equation

HRID 2235041 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:22][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:20]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33].[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].C(O)C>O>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:20][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:22]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33]

Participants

5

Reactant 3

HCID 702EthanolHCID 444266Maleic AcidHCID 68439913HCID 68439913, compound

Product 1

HCID 68439912HCID 68439912, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.

Workup

  1. dissolutionwere completely dissolved
  2. waitAfter the solution had been left
  3. temperatureto cool
  4. filtrationthe formed solid was collected through filtration

Sources & evidence

ORD record
ord-31725629c7b4403c8215b20a560bee53
Source dataset
uspto-grants-2010_05
Patent number
US07713997B2

Reaction notes

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