Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | HCID 68439913 | HCID 68439913 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68439912 | HCID 68439912 | — |
Reaction Steps
1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07713997B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-31725629c7b4403c8215b20a560bee53 |
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| Source note | uspto-grants-2010_05 |
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