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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2235041Generated: November 1, 2026

Ethanol → HCID 68439912, compound

https://huagongshe.com/reaction/2235041

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolHCID 702—
ReactantMaleic AcidHCID 444266—
ReactantHCID 68439913HCID 68439913—
SolventWaterHCID 962—
ProductHCID 68439912HCID 68439912—

Reaction Conditions

Temperature80 °C

Reaction Steps

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07713997B2
Source datasetuspto-grants-2010_05
ORD IDord-31725629c7b4403c8215b20a560bee53
Source noteuspto-grants-2010_05