HCID 68690173, compound → HCID 68688989, compound

HRID 2235045Notes

Reaction equation

HRID 2235045 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N:9]1[C:14](=[O:15])[CH2:13][CH2:12][C:11]([C:16]([O:18]CC2C=CC=CC=2)=[O:17])=[CH:10]1>C(O)C.[Pd]>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[N:9]1[C:14](=[O:15])[CH2:13][CH2:12][C:11]([C:16]([OH:18])=[O:17])=[CH:10]1

Participants

4

Reactant 1

HCID 68690173HCID 68690173, compound

Product 1

HCID 68688989HCID 68688989, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of the compound prepared in Example 46 (4.77 g) in ethanol (140 mL) was added 5% palladium/carbon (0.5 g) and the mixture was stirred at room temperature for 2 hours under an atmosphere of hydrogen. The reaction mixture was filtrated with Celite (proprietary name) and the filtrate was concentrated to give the compound of the present invention (2.93 g) having the following physical data.

Workup

  1. filtrationThe reaction mixture was filtrated with Celite (proprietary name)
  2. concentrationthe filtrate was concentrated
  3. customto give the compound of the present invention (2.93 g)

Sources & evidence

ORD record
ord-d33b55751d54445f82b40056ea86a859
Source dataset
uspto-grants-2010_05
Patent number
US07713998B2

Reaction notes

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