反应详情

0.6 g of N-[3-methyl-4-(pyrrolidine-1-sulphonyl)-phenyl]-acetamide (2.13 mmol) are dissolved in 5 ml of ethanol and then 10 ml hydrochloric acid (6 N) are added thereto at ambient temperature. The mixture is stirred overnight at ambient temperature and then extracted three times with dichloromethane. The combined organic phases are washed successively with 5% sodium hydrogen carbonate solution and water. The aqueous phase is re-extracted with dichloromethane and combined with the dichloromethane phase already present, dried over sodium sulphate and evaporated down. A yellow oil is obtained which slowly crystallises out.

1. customat ambient temperature
2. extractionextracted three times with dichloromethane
3. washThe combined organic phases are washed successively with 5% sodium hydrogen carbonate solution and water
4. extractionThe aqueous phase is re-extracted with dichloromethane
5. dry with materialdried over sodium sulphate
6. customevaporated down
7. customA yellow oil is obtained which
8. customslowly crystallises out