HCID 131728112, compound → HCID 67526328, compound

HRID 2235052Notes

Reaction equation

HRID 2235052 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N:16]2[C:20](=[O:21])[CH2:19][C@@H:18]([NH:22]C(=O)OCC3C=CC=CC=3)[CH2:17]2)[CH:5]=[CH:6][C:7]=1[S:8]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)(=[O:10])=[O:9].[H][H]>CO.[Pd]>[NH2:22][C@H:18]1[CH2:17][N:16]([C:4]2[CH:5]=[CH:6][C:7]([S:8]([N:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)(=[O:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)[C:20](=[O:21])[CH2:19]1

Participants

5

Reactant 2

HCID 131728112HCID 131728112, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67526328HCID 67526328, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

45 mg (98 μmol) benzyl(R)-{1-[3-methyl-4-(pyrrolidine-1-sulphonyl)-phenyl]-5-oxo-pyrrolidin-3-yl}-carbamate are dissolved in 10 ml of methanol, combined with 25 mg palladium on charcoal and hydrogenated for 8 hours in a Parr apparatus at 3 bar hydrogen pressure at ambient temperature.

Sources & evidence

ORD record
ord-c46d1e9a97c64696aced9c4089522a2b
Source dataset
uspto-grants-2010_05
Patent number
US07714000B2

Reaction notes

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