HCID 20264014, compound → HCID 20263935, compound

HRID 223516Notes

Reaction equation

HRID 223516 reaction equation
[CH3:1][C:2]1[C:7]([O:8]C(=O)C)=[C:6]([CH:12](O)[CH3:13])[C:5]([CH2:15][S:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:4][N:3]=1>COCCOCCOC>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH:12]=[CH2:13])[C:5]([CH2:15][S:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 20264014HCID 20264014, compound

Product 1

HCID 20263935HCID 20263935, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

The product from Step E (2 gm.) was added to diglyme and refluxed 3 hours. The mixture was evaporated to dryness to give 2-methyl-3-hydroxy-4-vinyl-5-benzoylthiomethylpyridine. This material was purified by chromatography on 800 gm. of silica gel by elution with 10% methanol in chloroform (v/v).

Workup

  1. temperaturerefluxed 3 hours
  2. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-5c28235c091448058b057df370a1a28a
Source dataset
uspto-grants-1982_10
Patent number
US04355034

Reaction notes

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