5-Chloro-2-methoxybenzene-1-sulfonyl chloride → 8-bromo-1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine

HRID 2235170Notes

Reaction equation

HRID 2235170 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][NH:7][C:6]=2[CH:12]=1.[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([O:24][CH3:25])=[C:18]([S:20](Cl)(=[O:22])=[O:21])[CH:19]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][N:7]([S:20]([C:18]3[CH:19]=[C:14]([Cl:13])[CH:15]=[CH:16][C:17]=3[O:24][CH3:25])(=[O:21])=[O:22])[C:6]=2[CH:12]=1

Participants

3

Reactant 2

HCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chlorideHCID 162444748-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Product 1

HCID 684350278-bromo-1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Procedure

8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine was reacted with 5-chloro-2-methoxybenzenesulfonyl chloride in analogy to example 34, step 2, yielding 8-bromo-1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine. Off-white solid, MS (ISP): m/e 430.2 (M+H).

Sources & evidence

ORD record
ord-56b7a819f4214434928af3029f74f11e
Source dataset
uspto-grants-2010_05
Patent number
US07713996B2

Reaction notes

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