反应详情

Combine trans-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-carbamic acid benzyl ester (23.0 g, 0.06 mol), palladium, 10% wt. on activated carbon (0.5 g), in EtOAc (100 mL) and charge the flask with hydrogen (50 psi). After 3 hours, filter the reaction mixture through a pad of Celite® and evaporate the solvent to obtain trans-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexylamine as a dark oil (14.4 g, 99%): MS (EI) m/z=229 (M+).

1. filtrationfilter the reaction mixture through a pad of Celite®
2. customevaporate the solvent