反应详情

温度

0 °C

Dissolve (4-benzyloxy-2,6-dichloro-phenyl)-methanol in 2.5 L THF and cool to 0° C. under N2. Add 94.45 g PBr3 dropwise and stir at 0° C. for 30 minutes. Pour the reaction mixture into sat'd. NaHCO3 and extract with EtOAc (2×). Dry over Na2SO4, filter and concentrate under vacuum to yield 269 g (89%) of the title compound as a white solid. MS (electrospray), 345.1, 347.1 (ES−).

1. additionPour the reaction mixture into sat'd
2. extractionNaHCO3 and extract with EtOAc (2×)
3. dry with materialDry over Na2SO4
4. filtrationfilter
5. concentrationconcentrate under vacuum