反应详情

Dissolve 3′-chloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-3-carboxylic acid tert-butyl ester (Preparation 82) (506 mg, 1.08 mmol) in methylene chloride (5 mL). Add trifluoroacetic acid (5 mL) and stir at room temperature for 1 hour. Concentrate and redissolve in methylene chloride. Pour into 1N NaOH. Extract with ether. Acidify aqueous phase to pH 1. Extract with ether. Dry over sodium sulfate, filter and concentrate to yield 420 mg (94%) of the title compound as a white solid. Mass spectrum (apci) m/z=410.3

1. concentrationConcentrate
2. dissolutionredissolve in methylene chloride
3. additionPour into 1N NaOH
4. extractionExtract with ether
5. extractionExtract with ether
6. dry with materialDry over sodium sulfate
7. filtrationfilter
8. concentrationconcentrate