Cycloheptylamine → HCID 11688683, compound

HRID 2235277Notes

Reaction equation

HRID 2235277 reaction equation
[Cl:1][C:2]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:3]=1[CH2:4][CH:5]1[CH2:9][CH2:8]O[C:6]1=[O:10].[CH:16]1([NH2:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([N:23]2[CH2:8][CH2:9][CH:5]([CH2:4][C:3]3[CH:11]=[CH:12][C:13]([Cl:15])=[CH:14][C:2]=3[Cl:1])[C:6]2=[O:10])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 59299396HCID 59299396, compound

Product 1

HCID 11688683HCID 11688683, compoundYield 33.1%

Conditions

Temperature
140 °C

Procedure

Charge vial with 3-(2,4-dichloro-benzyl)-dihydro-furan-2-one (300 mg, 1.2 mmol) and cycloheptylamine (139 mg, 1.2 mmol) and heat to 140° C. for 3 hours. Then heat to 195° C. overnight. Cool to room temperature and purify over silica gel which affords 135 mg (32%) of the title compound: Mass spectrum (apci) m/z=340.2 (M+H).

Workup

  1. temperatureThen heat to 195° C. overnight
  2. temperatureCool to room temperature
  3. custompurify over silica gel which

Sources & evidence

ORD record
ord-a18b9b6b614a4ac09ddd700f56759890
Source dataset
uspto-grants-2010_05
Patent number
US07713979B2

Reaction notes

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