Pyridine → HCID 59299489, compound

HRID 2235304Notes

Reaction equation

HRID 2235304 reaction equation
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[NH2:19][C:20]1[C:21]([Cl:40])=[C:22]([C:36]([Cl:39])=[CH:37][CH:38]=1)[CH2:23][CH:24]1[CH2:28][CH2:27][N:26]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:25]1=[O:35]>>[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8]([NH:19][C:20]2[CH:38]=[CH:37][C:36]([Cl:39])=[C:22]([CH2:23][CH:24]3[CH2:28][CH2:27][N:26]([CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)[C:25]3=[O:35])[C:21]=2[Cl:40])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 59299405HCID 59299405, compound

Product 1

HCID 59299489HCID 59299489, compoundYield 47.2%

Procedure

Using the procedure to synthesize Example 207 and using reagents 3-Chloro-2-methyl-benzenesulfonyl chloride (194 mg, 0.84 mmol), pyridine (0.07 mL, 0.84 mmol), and 3-(3-Amino-2,6-dichloro-benzyl)-1-cyclohexyl-pyrrolidin-2-one (Example 192) (240 mg, 0.70 mmol) affords 175 mg (47%) of the title compound: Mass spectrum (apci) m/z=529.05 (M+H).

Workup

  1. customto synthesize Example 207

Sources & evidence

ORD record
ord-8ca401d3209a41a4bac1cb20eed1f1bf
Source dataset
uspto-grants-2010_05
Patent number
US07713979B2

Reaction notes

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