Aniline → HCID 59299343, compound

HRID 2235316Notes

Reaction equation

HRID 2235316 reaction equation
Br[C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11]C[N:9]([CH:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[C:8]2=[O:19])=[C:4]([Cl:22])[CH:3]=1.[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:22][C:4]1[CH:3]=[C:2]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:5]=1[CH2:6][CH:7]1[CH2:12][CH2:11][N:9]([CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[C:8]1=[O:19]

Participants

3

Reactant 2

HCID 6115AnilineHCID 59299455HCID 59299455, compound

Product 1

HCID 59299343HCID 59299343, compoundYield 61%

Procedure

Prepare essentially as described in Example 228, using 3-(4-bromo-2-chloro-benzyl)-1-cyclohexyl-piperidin-2-one and aniline. Evaporate the crude reaction mixture and purify by chromatography on silica gel to give the title compound (127 mg, 61%). MS (ES+) m/z=383 (M+H)+.

Workup

  1. customPrepare essentially
  2. customEvaporate the crude
  3. customreaction mixture
  4. custompurify by chromatography on silica gel

Sources & evidence

ORD record
ord-372d106c75574e53ab7150dc64fcdefb
Source dataset
uspto-grants-2010_05
Patent number
US07713979B2

Reaction notes

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