HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2235318Generated: October 30, 2026
Hydrochloric Acid → 4-{3,5-Dichloro-4-[1-(4-hydroxy-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy}-benzoic acid methyl ester
https://huagongshe.com/reaction/2235318
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178498214 | HCID 178498214 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-{3,5-Dichloro-4-[1-(4-hydroxy-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy}-benzoic acid methyl ester | HCID 59299439 | — |
Reaction Steps
Dissolve 90 mg of 4-(4-{1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-3-ylmethyl}-3,5-dichloro-phenoxy)-benzoic acid methy ester (Preparation 73) in 10 mL EtOH and treat with 1 mL 1 N aqueous HCl. Heat at 60° C. for 2 hours. Concentrate to dryness under vacuum and purify by radial chromatography using 5% MeOH in CHCl3 to recover 73 mg of product. Mass spectrum (api-es) m/z 492 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07713979B2 |
|---|
| Source dataset | uspto-grants-2010_05 |
|---|
| ORD ID | ord-1345527332af464d9d77288e324771e0 |
|---|
| Source note | uspto-grants-2010_05 |
|---|
