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HRID2235318

反应详情

EQUATION

反应方程式

HRID 2235318 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COC(=O)c1ccc(Oc2cc(Cl)c(CC3CCN([C@H]4CC[C@@H](O[Si](C)(C)C(C)(C)C)CC4)C3=O)c(Cl)c2)cc1
HCID178498214

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(Oc2cc(Cl)c(CC3CCN(C4CCC(O)CC4)C3=O)c(Cl)c2)cc1
HCID59299439

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

Dissolve 90 mg of 4-(4-{1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-2-oxo-pyrrolidin-3-ylmethyl}-3,5-dichloro-phenoxy)-benzoic acid methy ester (Preparation 73) in 10 mL EtOH and treat with 1 mL 1 N aqueous HCl. Heat at 60° C. for 2 hours. Concentrate to dryness under vacuum and purify by radial chromatography using 5% MeOH in CHCl3 to recover 73 mg of product. Mass spectrum (api-es) m/z 492 (M+H).

WORKUP

后处理

  1. concentrationConcentrate to dryness under vacuum
  2. custompurify by radial chromatography
  3. customto recover 73 mg of product