Hydrochloric Acid → Methyl 6-methylnicotinate

HRID 223534Notes

Reaction equation

HRID 223534 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.Cl.[CH3:12]O>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:12])=[O:7])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1378606-Methylnicotinic acid

Product 1

HCID 231548Methyl 6-methylnicotinate

Procedure

6-Methylnicotinic acid (0.1 mole) is refluxed in 100 ml. of methanol saturated with gaseous hydrogen chloride for 1 hour and then evaporated to dryness. The residue is stirred saturated aqueous sodium bicarbonate solution and the product is extracted into chloroform. The chloroform extract is dried and concentrated to dryness to give methyl 6-methylnicotinate.

Workup

  1. customevaporated to dryness
  2. extractionthe product is extracted into chloroform
  3. extractionThe chloroform extract
  4. customis dried
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-6ddf54cf4ed44f56976d57527eb60622
Source dataset
uspto-grants-1982_10
Patent number
US04355034

Reaction notes

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