反应详情

Methyl 6-methylnicotinate (0.05 mole) is stirred in dry tetrahydrofuran (50 ml.) at 10° C. while solid lithium aluminum hydride (0.0125 mole) is added over one hour. Water (10 ml.) is added with stirring, and the mixture is concentrated to dryness. The residue is extracted several times with hot isopropanol and the combined extracts are filtered and concentrated to dryness to give 2-methyl-5-hydroxymethylpyridine.

1. additionis added over one hour
2. concentrationthe mixture is concentrated to dryness
3. extractionThe residue is extracted several times with hot isopropanol
4. filtrationthe combined extracts are filtered
5. concentrationconcentrated to dryness