HCID 23092664, compound → HCID 59300807, compound

HRID 2235398Notes

Reaction equation

HRID 2235398 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][C:16]=1[N+:17]([O-])=O)[N:13]([CH2:20][CH3:21])[C:12](=[O:22])[C:11]2([CH3:24])[CH3:23])=O>[Ni]>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[NH:7][C:8]3=[CH:9][C:10]4[C:11]([CH3:24])([CH3:23])[C:12](=[O:22])[N:13]([CH2:20][CH3:21])[C:14]=4[CH:15]=[C:16]3[N:17]=2)[CH:25]=[CH:26][N:27]=1

Participants

3

Reactant 1

HCID 23092664HCID 23092664, compound

Product 1

HCID 59300807HCID 59300807, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

2-(2-Chloro-pyridin-4-yl)-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one is prepared from 2-chloro-N-(1-ethyl-3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-isonicotinamide (230 mg) as described in Example 1b using Raney-nickel (50 mg) instead of Pd/C. After filtration the filtrate is poured into ice-water and the precipitate is collected by filtration to give the desired compound (140 mg).

Workup

  1. filtrationAfter filtration the filtrate
  2. additionis poured into ice-water
  3. filtrationthe precipitate is collected by filtration

Sources & evidence

ORD record
ord-c4270a97b4b34fe0a4bc91b42ed08246
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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