反应详情

(E)-N-(3,3-Dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-3-(2-nitrophenyl)-acrylamide is dissolved in EtOAc (70 ml). SnCl2.H2O (5.44 g; 24.1 mmol) is added and the resulting mixture is heated under reflux for 20 h. After re-cooling the mixture is filtered over basic Al2O3 (120 g) and concentrated in vacuo. The residue is taken-up in EtOAc and saturated K2CO3 solution. After an aqueous work-up the compound (0.82 g) is obtained as a yellow solid.

1. temperaturethe resulting mixture is heated
2. temperatureunder reflux for 20 h
3. temperatureAfter re-cooling the mixture
4. filtrationis filtered over basic Al2O3 (120 g)
5. concentrationconcentrated in vacuo