5-Amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one → 3-(3-Amino-phenyl)-N-(3,3-dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-propionamide

HRID 2235409Notes

Reaction equation

HRID 2235409 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].[NH2:22][C:23]1[CH:24]=[C:25]([CH2:29][CH2:30][C:31](Cl)=[O:32])[CH:26]=[CH:27][CH:28]=1>>[NH2:22][C:23]1[CH:24]=[C:25]([CH2:29][CH2:30][C:31]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][C:10]=2[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]3([CH3:20])[CH3:21])=[O:32])[CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 178027445-Amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-oneHCID 230926613-(3-Amino-phenyl)-propionyl chloride

Product 1

HCID 230926703-(3-Amino-phenyl)-N-(3,3-dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-propionamide

Procedure

The compound is synthesized from A8 (213 mg) and freshly prepared 3-(3-amino-phenyl)-propionyl chloride (223 mg; 1.21 mmol) as described in Example 1a.

Sources & evidence

ORD record
ord-c104b7bfab444d4bb93d6b99ccf5cb60
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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