HCID 23092672, compound → HCID 59300794, compound

HRID 2235426Notes

Reaction equation

HRID 2235426 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]([NH:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][C:20]=2[NH:21][CH3:22])[N:17]([CH3:23])[C:16](=[O:24])[C:15]3([CH3:26])[CH3:25])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)(=O)C>[CH3:22][N:21]1[C:20]2[C:12](=[CH:13][C:14]3[C:15]([CH3:26])([CH3:25])[C:16](=[O:24])[N:17]([CH3:23])[C:18]=3[CH:19]=2)[N:11]=[C:9]1/[CH:8]=[CH:7]/[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 23092672HCID 23092672, compound

Product 1

HCID 59300794HCID 59300794, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of (E)-3-phenyl-N-(1,3,3-trimethyl-6-methylamino-2-oxo-2,3-dihydro-1H-indol-5-yl)-acrylamide (288 mg) in acetic acid (6 ml) is heated under reflux for 1 h. After recooling the mixture is poured into ice-water whereupon the desired compound (250 mg) is precipitated.

Workup

  1. temperatureunder reflux for 1 h

Sources & evidence

ORD record
ord-2485e187091249edb8996026afb40c92
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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