HCID 67425975, compound → HCID 67426623, compound

HRID 2235430Notes

Reaction equation

HRID 2235430 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][C:3]=1[NH:15][C:16](=O)[CH2:17][CH2:18][C:19]1[CH:27]=[CH:26][C:22]2[O:23][CH2:24][O:25][C:21]=2[CH:20]=1>C(O)(=O)C>[O:23]1[C:22]2[CH:26]=[CH:27][C:19]([CH2:18][CH2:17][C:16]3[NH:15][C:3]4=[CH:4][C:5]5[C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=5[CH:10]=[C:2]4[N:1]=3)=[CH:20][C:21]=2[O:25][CH2:24]1

Participants

3

Reactant 1

HCID 67425975HCID 67425975, compound

Product 1

HCID 67426623HCID 67426623, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N-(6-amino-1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-3-benzo[1,3]dioxol-5-yl-propionamide (60 mg) in acetic acid (1.6 ml) is heated in a microwave apparatus at 150° C. for 15 min. After dilution with water the mixture is extracted with EtOAc (3×15 ml). The organic layer is washed with brine, dried over MgSO4 and concentrated in vacuo to give the desired compound (57 mg).

Workup

  1. extractionAfter dilution with water the mixture is extracted with EtOAc (3×15 ml)
  2. washThe organic layer is washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-58d1941c75124d5c91e183c3d07f5351
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

Loading…