HCID 67427131, compound → 1H-Imidazole-2-propanoic acid, 1-methyl-, methyl ester

HRID 2235431Notes

Reaction equation

HRID 2235431 reaction equation
[CH3:1][O:2][C:3](=[O:12])/[CH:4]=[CH:5]/[C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1

Participants

4

Reactant 1

HCID 67427131HCID 67427131, compound

Product 1

HCID 674269261H-Imidazole-2-propanoic acid, 1-methyl-, methyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(E)-3-(1-Methyl-1H-imidazol-2-yl)-acrylic acid methyl ester (0.86 g) is dissolved in MeOH (10 ml) and hydrogenated at 3 bar at RT for 2 h using Pd/C (10%, 0.1 g) as catalyst. After filtration and evaporation of the solvent the compound (0.87 g) is obtained.

Workup

  1. filtrationAfter filtration and evaporation of the solvent the compound (0.87 g)
  2. customis obtained

Sources & evidence

ORD record
ord-a35faaa769714fa3b1d6fbd0beced650
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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