Nitric Acid → HCID 67426568, compound

HRID 2235450Notes

Reaction equation

HRID 2235450 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]2([CH2:12][CH2:11]2)[C:3]1=[O:13].[N+:14]([O-])([OH:16])=[O:15].O>C(O)(=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:14]([O-:16])=[O:15])=[CH:8][CH:9]=2)[C:4]2([CH2:12][CH2:11]2)[C:3]1=[O:13]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 14317864HCID 14317864, compound

Product 1

HCID 67426568HCID 67426568, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 1′-methyl-spiro[cyclopropane-1,3′-indoline]-2′-one (8 g) in acetic acid (150 ml) is added nitric acid (fuming, 5.5 ml) over a period of 15 min at 15° C. The mixture is stirred at RT for 3 h and then poured into water. The precipitate is collected by filtration and washed with water, 2-propanol and tertbutyl-methyl-ether to give the title compound (8.80 g).

Workup

  1. filtrationThe precipitate is collected by filtration
  2. washwashed with water, 2-propanol and tertbutyl-methyl-ether

Sources & evidence

ORD record
ord-8fecf14a0f7d4f4d9c26c08388ddc859
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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