HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 5-Amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one | HCID 17802744 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one | HCID 67427492 | 35% |
Reaction Steps
A8 (0.5 g) is alkylated using 2-iodopropane (0.5 ml; 5 mmol) and KOtBu (561 mg; 5 mmol) in N,N-dimethylformamide (7 ml) for 20 h at RT. After aqueous work-up and flash chromatography on silica gel eluting with CH2Cl2/MeOH (98:2) the compound (200 mg) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714010B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5f6103573be5451189778331726472e7 |
| Source note | uspto-grants-2010_05 |