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HRID2235458

反应详情

EQUATION

反应方程式

HRID 2235458 的结构方程式

REACTANTS

反应物

4
结构：CC(C)I
HCID6362

2-Iodopropane

C3H7I

结构：CCCCCN1C(=O)C(C)(C)c2cc(N)c([N+](=O)[O-])cc21
HCID17802744

未命名化合物

结构：CO.ClCCl
HCID21226129

未命名化合物

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

1
结构：CCCCCN1C(=O)C(C)(C)c2cc(NC(C)C)c([N+](=O)[O-])cc21
HCID67427492

未命名化合物

收率 35%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A8 (0.5 g) is alkylated using 2-iodopropane (0.5 ml; 5 mmol) and KOtBu (561 mg; 5 mmol) in N,N-dimethylformamide (7 ml) for 20 h at RT. After aqueous work-up and flash chromatography on silica gel eluting with CH2Cl2/MeOH (98:2) the compound (200 mg) is obtained.

WORKUP

后处理

  1. customfor 20 h
  2. customat RT