HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → 1-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-3-phenyl-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 2-Amino-7,7-dimethyl-5-pentyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one | HCID 59300824 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-3-phenyl-urea | HCID 59300829 | 63.3% |
Reaction Steps
A solution of D5 (172 mg) and phenyl isocyanate (72 mg; 0.6 mmol) in acetone (3 ml) is stirred at RT for 3 days. Acetone is evaporated and the residue is purified by flash chromatography on silica gel eluted with CH2Cl2/MeOH (20:1) to give the desired compound (154 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714010B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-c55a761541d94927947765f25eff7561 |
| Source note | uspto-grants-2010_05 |