Benzylamine → HCID 59300953, compound

HRID 2235481Notes

Reaction equation

HRID 2235481 reaction equation
Cl[C:2]1[NH:21][C:5]2=[CH:6][C:7]3[C:8]([CH3:20])([CH3:19])[C:9](=[O:18])[N:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:11]=3[CH:12]=[C:4]2[N:3]=1.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([NH:29][C:2]1[NH:21][C:5]2=[CH:6][C:7]3[C:8]([CH3:20])([CH3:19])[C:9](=[O:18])[N:10]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:11]=3[CH:12]=[C:4]2[N:3]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 59300882HCID 59300882, compound

Product 1

HCID 59300953HCID 59300953, compoundYield 10.6%

Conditions

Temperature
200 °C

Procedure

A mixture of F1 (100 mg) and benzylamine (1.5 ml; 13.6 mmol) is stirred in a microwave apparatus at 200° C. for 8 min. After re-cooling the mixture is concentrated in vacuo and purified by RP-MPLC (Polygoprep 100-50 C18) eluting with a water/MeCN gradient to give the desired compound (13 mg).

Workup

  1. temperatureAfter re-cooling the mixture
  2. concentrationis concentrated in vacuo
  3. custompurified by RP-MPLC (Polygoprep 100-50 C18)
  4. washeluting with a water/MeCN gradient

Sources & evidence

ORD record
ord-0c994dc7f2d94fb1b47eda75ddb13c09
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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