反应详情

To 0.075 g (0.28 mmol) of 2-morpholin-4-yl-7-nitro-1,3-benzothiazole in 6 mL of tetrahydrofuran (THF) was added a pipet tip of Raney nickel. The reaction was kept under a hydrogen atmosphere via a balloon and stirred at room temperature for 5 h. The catalyst was removed via filtration and the filtrate was concentrated in vacuo. Purification by flash chromatography failed to provide clean B so the 0.022 g (33%) of material thus isolated was used without further purification.

1. customThe catalyst was removed via filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customPurification by flash chromatography