Sodium borohydride → HCID 86049098, compound

HRID 2235515Notes

Reaction equation

HRID 2235515 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([N+:22]([O-:24])=[O:23])[C:6]2[S:10][C:9]([NH:11][C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])=[N:8][C:7]=2[CH:21]=1.[BH4-].[Na+]>CS(C)=O.O.Cl>[C:13]1([CH3:20])[CH:14]=[C:15]([CH3:19])[CH:16]=[C:17]([CH3:18])[C:12]=1[NH:11][C:9]1[S:10][C:6]2[C:5]([N+:22]([O-:24])=[O:23])=[CH:4][C:3]([CH3:2])=[CH:21][C:7]=2[N:8]=1

Participants

6

Reactant 2

HCID 4311764Sodium borohydrideHCID 86049094HCID 86049094, compound

Product 1

HCID 86049098HCID 86049098, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

To a solution of 5-chloromethyl-N-mesityl-7-nitro-1,3-benzothiazol-2-amine (120 mg, 0.332 mmol) in dimethyl sulfoxide (DMSO) (2 ml) was added sodium borohydride (25 mg, 0.663 mmol). The mixture was stirred at room temperature for 3 h and diluted with water and neutralized with 1N HCl solution. The aqueous solution was extracted with AcOEt.

Workup

  1. extractionThe aqueous solution was extracted with AcOEt

Sources & evidence

ORD record
ord-212b0a11416c47b3a3d47062df7b4133
Source dataset
uspto-grants-2010_05
Patent number
US07714009B2

Reaction notes

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