反应详情

To a solution containing 0.25 g (0.79 mmol) of 1-(3-amino-2-methylaminophenyl)-3-mesitylthiourea in acetonitrile was added 0.52 g (1.6 mmol) of mercury (II) chloride, and the mixture stirred for 1 h. The reaction mixture was diluted with ethyl acetate (2 ml) and filtered through a prepacked celite column. The filtrate was concentrated under reduced pressure and the residue purified via Biotage chromatography eluting with 20% ethyl acetate/dichloromethane to afford 0.12 g (55%) of product.

1. filtrationfiltered through a prepacked celite column
2. concentrationThe filtrate was concentrated under reduced pressure
3. customthe residue purified via Biotage chromatography
4. washeluting with 20% ethyl acetate/dichloromethane